Relation of inflammation and reactive oxygen spcies (ROS)

Background: Inflammation has been recognized to be related to development of many metabolic complications. ROS are highly reactive molecules that –when present in high levels– are strongly related to metabolic complications as well. Indeed, metabolic diseases are accompanied by both chronic low-grade inflammation and increased ROS levels.

Questions: How is inflammation related to ROS, and what is the metabolic consequence of this interaction? Is this interaction influenced by physiological status like overweight/obese, or insulin resistant versus healthy? Is this interaction influenced by nutritional status? Is this interaction the same in mice and man?

Aims: Integrate results from research papers to create an overview about one or more questions related to this topic (exact topic to be determined with supervisor).