The role of the nicotinamide nucleotide transhydrogenase (Nnt) gene in metabolic complications

Background: The Nnt protein plays a crucial role in removing reactive oxygen species (ROS) in the mitochondria of cells. ROS are highly reactive molecules that –when present in high levels– are strongly related to metabolic complications. A Nnt-mutation in mice has been linked to enhanced susceptibility to diet-induced obesity and impaired glucose homeostasis.

Questions: What is the precise role of the Nnt gene in energy metabolism? Is this role influenced by physiological status like overweight/obese, or insulin resistant versus healthy? Is this role influenced by nutritional status? Is this role the same in mice and man?

Aims: Integrate results from research papers to create an overview about one or more questions related to this topic (exact topic to be determined with supervisor).