dr. JJE (Jolien) van Hooff
Universitair docentFollow me:
I am intrigued by the origins, complexity and diversity of eukaryotic cells. Eukaryotes share many intracellular features, but their cells and underlying regulatory systems also exhibit an enormous diversity. This complexity and diversity result from diverse mechanisms of molecular and genome evolution, which I aim to elucidate and explain. Such mechanisms include gene divergence, loss, duplication, and lateral gene transfer. My approach predominantly comprises tracing the evolution of proteins using bioinformatics. I am trained both in small-scale, tailored analysis of individual protein families as well as in large-scale comparative genomics and phylogenetics.
2023-current Mining the Investigating the role of gene fusion and de novo genes during the prokaryote-to-eukaryote transition (Wageningen University & Research, Thijs Ettema)
2020-2022 Tempo, targets and traits of lateral gene transfer in eukaryotes (Université Paris- Saclay, Postdoc Laura Eme)
2018-2019 Policy researcher at Court of Audit Rotterdam (non-academic job, Rekenkamer Rotterdam)
2013-2018 Origins and divergence of the eukaryotic kinetochore (PhD project, Utrecht University and KNAW-Hubrecht Institute, Berend Snel and Geert Kops)
2017 Timing of large-scale gene duplications during eukaryogenesis (EMBO Short-Term Fellowship, Centre for Genomic Regulation, Barcelona, Toni Gabaldón)
2013 The effects of juvenile infection on adult fitness in Drosophila melanogaster (MSc project, University College London, Jennifer Regan)
2011-2012 Genome evolution of the plant pathogen Phytophthora (MSc project, Utrecht University, Michael Seidl)