Laboratory of Biochemistry

Biochemistry is the study of the chemistry of life processes. Our research focuses on how proteins form, function and degrade inside cells. In short: "Cellular Biochemistry".

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Our Education

The Laboratory of Biochemistry provides a number of lecture series and practical courses for students.

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Selected publications

Visualization of BRI1 and BAK1(SERK3) membrane receptor heterooligomers during brassinosteroid signaling. Bücherl CA, van Esse GW, Kruis A, Luchtenberg J, Westphal AH, Aker J, van Hoek A, Albrecht C, Borst JW, de Vries SC. Plant Physiol. 2013 Aug;162(4):1911-25. doi: 10.1104/pp.113.220152.

Structural Basis for DNA Binding Specificity by the Auxin-Dependent ARF Transcription Factors. Boer, D.R.*, Freire-Rios, A.*, van den Berg, W.A.*, Saaki, T., Manfield, I.W., Kepinski, S., López-Vidrieo, I., Franco-Zorrilla, J.M., de Vries, S.C., Solano, R., Weijers, D.*, Coll, M.* Cell. 2014 Jan 30;156(3):577-89. doi: 10.1016/j.cell.2013.12.027

Crystal structure of 3-hydroxybenzoate 6-hydroxylase uncovers lipid-assisted flavoprotein strategy for regioselective aromatic hydroxylation. Montersino S, Orru R, Barendregt A, Westphal AH, van Duijn E, Mattevi A, van Berkel WJ. J Biol Chem. 2013 Sep 6;288(36):26235-45. doi: 10.1074/jbc.M113.479303. Epub 2013 Jul 17.

MetIDB: a publicly accessible database of predicted and experimental 1H NMR spectra of flavonoids. Mihaleva VV, te Beek TA, van Zimmeren F, Moco S, Laatikainen R, Niemitz M, Korhonen SP, van Driel MA, Vervoort J. Anal Chem. 2013 Sep 17;85(18):8700-7. doi: 10.1021/ac4016837. Epub 2013 Aug 26.

Distant residues mediate picomolar binding affinity of a protein cofactor. Bollen YJ, Westphal AH, Lindhoud S, van Berkel WJ, van Mierlo CP. Nat Commun. 2012;3:1010. doi: 10.1038/ncomms2010.

Global analysis of FRET-FLIM data in live plant cells. Laptenok SP, Snellenburg JJ, Bücherl CA, Konrad KR, Borst JW. Methods Mol Biol. 2014;1076:481-502. doi: 10.1007/978-1-62703-649-8_21.